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Adaptive immune responses, mediated by T and B cells, produce autoantibodies, including anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF), forming immune complexes that exacerbate synovial damage (13)

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Self-treatment can lead to addiction to NSAIDs and serious consequences related to changes in the digestive system, kidneys, liver, or respiratory system in people with asthma